Saving very small test pages works fine, but as soon as a larger page is to be saved, nothing is saved and the Wiki says “This topic does not exist”.
When your pages are very large and and contain a lot of complex markup like tables, you could hit a memory limit. Try increasing the memory_limit option in your php.ini.
When it happens even on medium sized pages, you may have a variable size restriction in your PHP install. Known modules to do this are suhosin and varfilter. You need to increase or disable the filter values for the used module in your php.ini. Look for the following values:
varfilter.max_array_depth varfilter.max_request_variables varfilter.max_value_length varfilter.max_varname_length suhosin.request.max_array_depth suhosin.request.max_array_index_length suhosin.request.max_totalname_length suhosin.request.max_value_length suhosin.request.max_vars suhosin.request.max_varname_length